Michael J Rogers Selected Research

NE 21650

1/2002

Identification of a bisphosphonate that inhibits isopentenyl diphosphate isomerase and farnesyl diphosphate synthase.

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Michael J Rogers Research Topics

Disease

24	Bone Resorption 10/2020 - 01/2002
9	Neoplasms (Cancer) 09/2017 - 10/2006
5	Bone Diseases (Bone Disease) 10/2020 - 06/2006
5	Osteoporosis 10/2020 - 06/2006
5	Acute-Phase Reaction 07/2011 - 02/2004
4	Multiple Myeloma 09/2017 - 11/2002
3	Mevalonate Kinase Deficiency 01/2019 - 11/2016
3	Breast Neoplasms (Breast Cancer) 01/2015 - 11/2008
3	Neoplasm Metastasis (Metastasis) 05/2009 - 11/2007
2	Infections 12/2021 - 03/2021
2	Osteolysis 11/2008 - 10/2006
2	Osteopetrosis 08/2007 - 04/2007
2	Metabolic Bone Diseases (Osteopenia) 10/2006 - 02/2004
1	Respiratory Tract Infections (Respiratory Tract Infection) 12/2021
1	Pneumonia (Pneumonitis) 12/2021
1	Osteomyelitis 03/2021
1	Calcinosis 01/2015
1	Osteosarcoma (Osteogenic Sarcoma) 02/2012
1	hereditary expansile Polyostotic osteolytic dysplasia 08/2011
1	Severe Combined Immunodeficiency (Bare Lymphocyte Syndrome) 01/2010
1	Plasmacytoma 01/2010
1	Experimental Melanoma 05/2009
1	Inflammation (Inflammations) 01/2009
1	Necrosis 01/2009
1	Rheumatoid Arthritis 01/2009
1	Melanoma (Melanoma, Malignant) 11/2008
1	Agammaglobulinemia (Hypogammaglobulinemia) 07/2008
1	Osteitis Deformans (Paget's Disease of Bone) 11/2007
1	Prostatic Neoplasms (Prostate Cancer) 03/2007
1	Hypercalcemia (Milk Alkali Syndrome) 10/2006

Drug/Important Bio-Agent (IBA)

25	Diphosphonates (Bisphosphonates)IBA 12/2021 - 05/2002
13	NitrogenIBA 12/2021 - 05/2002
7	Zoledronic Acid (Zometa)FDA Link 10/2015 - 11/2002
5	Alendronate (Alendronate Sodium)FDA LinkGeneric 01/2009 - 01/2002
4	GeranyltranstransferaseIBA 10/2006 - 01/2002
3	Mevalonic Acid (Mevalonate)IBA 12/2021 - 06/2006
3	Pharmaceutical PreparationsIBA 10/2020 - 01/2009
3	EnzymesIBA 01/2018 - 06/2006
3	Monomeric GTP-Binding ProteinsIBA 10/2015 - 05/2006
3	LigandsIBA 06/2010 - 08/2007
3	farnesyl pyrophosphate (farnesyl diphosphate)IBA 05/2010 - 05/2006
3	Proteins (Proteins, Gene)FDA Link 05/2009 - 09/2005
3	Clodronic Acid (Clodronate)IBA 01/2009 - 05/2002
2	Hydroxymethylglutaryl CoA Reductases (HMG CoA Reductase)IBA 02/2012 - 01/2003
2	MineralsIBA 07/2011 - 11/2008
2	Risedronic Acid (Actonel)FDA LinkGeneric 05/2010 - 11/2008
2	Bone Density Conservation AgentsIBA 10/2006 - 05/2002
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 02/2004 - 01/2003
1	Anti-Bacterial Agents (Antibiotics)IBA 03/2021
1	CalciumIBA 10/2020
1	mevalonate kinaseIBA 01/2019
1	Melphalan (Alkeran)FDA LinkGeneric 09/2017
1	Biomarkers (Surrogate Marker)IBA 01/2017
1	CholesterolIBA 11/2016
1	rab GTP-Binding ProteinsIBA 11/2016
1	apomine (SR 45023A)IBA 02/2012
1	Lovastatin (Mevacor)FDA LinkGeneric 02/2012
1	Protein Sorting Signals (Signal Peptide)IBA 08/2011
1	Fluvastatin FDA Link 07/2011
1	CytokinesIBA 07/2011
1	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 06/2010
1	lysophosphatidylinositolIBA 06/2010
1	AcidsIBA 05/2010
1	Poly(ADP-ribose) Polymerases (Poly ADP Ribose Polymerase)IBA 01/2010
1	LipopolysaccharidesIBA 01/2009
1	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2009
1	Macrophage Colony-Stimulating FactorIBA 01/2009
1	NF-kappa B (NF-kB)IBA 01/2009
1	Cytokine Receptors (Cytokine Receptor)IBA 01/2009
1	2- (3- pyridinyl)- 1- hydroxyethylidene- 1,1- phosphonocarboxylic acidIBA 11/2008
1	Immunoglobulins (Immunoglobulin)IBA 07/2008
1	Small Interfering RNA (siRNA)IBA 03/2007
1	IntegrinsIBA 03/2007
1	OsteopontinIBA 03/2007
1	Guanosine Triphosphate (GTP)IBA 05/2006
1	GTP Phosphohydrolases (GTPases)IBA 05/2006
1	Ibandronic Acid (Boniva)FDA Link 02/2003
1	Adenosine Triphosphate (ATP)IBA 02/2003
1	cerivastatin (Kazak)FDA Link 01/2003
1	Parathyroid Hormone (Parathormone)IBA 01/2003
1	Pamidronate (Aredia)FDA LinkGeneric 11/2002
1	GTP-Binding Proteins (G-Protein)IBA 05/2002
1	Adenosine Diphosphate (ADP)IBA 05/2002
1	LipidsIBA 05/2002
1	Terpenes (Terpenoids)IBA 05/2002
1	ATP Translocases Mitochondrial ADPIBA 05/2002
1	NE 21650IBA 01/2002

Therapy/Procedure

6	Therapeutics 12/2015 - 02/2004
1	Drug Therapy (Chemotherapy) 09/2017
1	Ovariectomy (Oophorectomy) 05/2011